Profhilo, by IBSA, is a high concentration hyaluronic acid treatment that works on firmness and hydration. Rejuran, by PharmaResearch, is a polynucleotide treatment that focuses on repair, texture and resilience. One firms. The other repairs.
The question we hear most at the front desk is a simple one. "Do I actually have to choose between Profhilo and Rejuran?" Most of the time, the honest answer is no. People talk about these two as if they are rivals, but they do quite different jobs. Profhilo, made by IBSA, is a high concentration hyaluronic acid treatment that works on firmness and hydration. Rejuran, made by PharmaResearch, is a polynucleotide treatment sourced from salmon DNA, and it focuses on repair, texture and resilience. Both are skin boosters, not fillers, so neither one adds volume to your face. What follows walks you through deciding by your own skin goal, with every medical call left to a DHA licensed practitioner.
Profhilo is an injectable skin booster made by IBSA. The active ingredient is a high concentration of hyaluronic acid, delivered through a formulation IBSA calls NAHYCO technology. A dermal filler stays put in one spot to plump an area. Profhilo behaves differently. The hyaluronic acid spreads through the skin and supports what is often described as a bioremodelling effect. In plain terms, it nudges your own fibroblast cells to produce more collagen and elastin, and that is what lifts firmness and improves hydration over time.
So when do people reach for it? Usually when the main concern is mild skin laxity, a softer looking jawline, or skin that has lost a bit of its bounce and glow across the lower face and neck. It is not a filler, which means it improves the quality of your skin rather than changing its shape. If you have ever worried about looking done or overdone, that distinction matters.
For a fuller look at the treatment itself, see our guide to Profhilo in Dubai.
Rejuran is an injectable skin booster made by PharmaResearch. Its active ingredient is a polynucleotide, sometimes written as PN or PDRN, sourced from salmon DNA. Where Profhilo leans into firmness, Rejuran leans into repair and healing. It is most associated with improving skin texture, building resilience, and supporting more delicate or stressed skin. It is also the treatment most people ask about for the under eye area.
Like Profhilo, Rejuran works through your fibroblast cells and the collagen and elastin they produce, so it too is improving skin quality from within. It is commonly chosen for concerns like uneven texture, acne scars, visible pores, and skin that feels sensitive or run down. And, importantly, it is not a filler either. No added volume, no reshaping of your features.
For more detail on the treatment on its own, see our guide to the Rejuran skin booster in Dubai.
Here is the single idea that makes this whole comparison click. Profhilo, with its high concentration hyaluronic acid, is a bioremodelling treatment aimed at firmness, hydration and mild laxity. Rejuran, with its polynucleotide from salmon DNA, is a repair and healing treatment aimed at texture and resilience. One firms. The other repairs.
High concentration hyaluronic acid, bioremodelling for firmness, hydration and mild laxity across the lower face, jawline and neck.
Polynucleotide from salmon DNA, repair and healing for texture, resilience and the delicate under eye area.
What surprises a lot of people is that both act on the same underlying machinery: your fibroblast cells, and the collagen and elastin they build. That shared node is exactly why they end up complementary rather than redundant. They reach skin quality from two different directions, which is the reason combining them tends to make sense rather than feel like doubling up.
It is worth saying plainly that neither one is a dermal filler. Fillers add volume and reshape. Profhilo and Rejuran improve the skin itself. They are also different from PRP, mesotherapy and neurotoxin treatments such as Botox, which do other jobs entirely. So if your worry has been looking unnatural, that concern belongs to the volumising world, not to either of these two.
Here is the side by side, kept balanced so you can scan the differences quickly.
Read the table from the top down and the pattern stays consistent. Profhilo is the firmness and hydration option for the lower face, jawline and neck. Rejuran is the repair and texture option that also leads on the under eye area. The downtime is broadly similar for both, since each is delivered through small microinjection points.
Profhilo is usually the starting point when the goal is firmness, mild skin laxity and hydration. Picture skin along the lower face, jawline and neck that has softened a little and lost some of its glow. Because it works on bounce and quality rather than shape, it is a common pick for both men and women who want their skin to look firmer and fresher without looking altered. Plenty of men ask about it specifically for a crisper looking jawline and neck.
Rejuran is generally the lead for repair and texture. That covers uneven texture, acne scars, visible pores, and skin that feels sensitive, stressed or damaged. It is also the one most people are asking about when they mention the under eye area and tired looking eyes. If your main concern sits around the eyes, Rejuran is usually where we begin, confirmed in consultation. This applies equally to men and women. Under eye texture and tired looking skin are not gender specific concerns, and we see both at the front desk asking about exactly this.
This is where we like to be honest, because you will find very different numbers floating around online. We attribute each figure to its product rather than stating anything as an absolute, because individual results genuinely vary.
Profhilo results are commonly described as lasting up to around six months, and a typical plan is two sessions spaced about four weeks apart. Rejuran is usually delivered as a course of three to four sessions, with gradual results that build over the course rather than landing all at once. Neither of these is a fixed promise. How your skin responds, where you are starting from, what you are aiming for, all of it shapes the plan, which is set with a DHA licensed practitioner in consultation rather than off a chart.
Yes. And this is usually the part that settles the "do I have to choose" worry for good. Because both treatments work through the same fibroblast, collagen and elastin pathway from two different angles, they are genuinely complementary. Many plans use both, with each treatment doing the job it does best.
Which brings us to the practical question: the order, and the spacing. Some people start with firmness through Profhilo and then move to repair through Rejuran. Others approach it zone by zone, say firmness across the lower face and jawline while Rejuran handles the under eye area and texture. Whether the two are spaced across separate visits, or in some cases considered within a closer schedule, depends on your skin and your plan. That sequencing call sits with a DHA licensed practitioner, who will map out what to do first and how far apart to space things. There is no single right order that fits everyone, which is exactly why it is decided in consultation rather than from a blog.
If you take one thing from this page, let it be this. Choose by the job you need done, not by which brand sounds better.
Neither Profhilo nor Rejuran is universally better than the other. They are built for different concerns, and they apply equally to men and women. The friendly version of all this is the one we give at the desk: tell us what bothers you most when you look in the mirror, and that points fairly quickly to one, the other, or both.
Which is better, Profhilo or Rejuran? Neither is universally better. Profhilo, by IBSA, leads on firmness, hydration and mild laxity. Rejuran, by PharmaResearch, leads on repair, texture, resilience and the under eye area. The right choice depends on your goal, and the two are often combined for the best of both.
Not sure which fits your goal? Send us your main skin concern on WhatsApp and we will tell you which one, or whether both, suits you, with the medical call confirmed by a DHA licensed practitioner.
Cost is the natural next question, and the honest answer is that it depends on your plan: how many sessions you have, and how many areas are treated. Because Profhilo and Rejuran follow different session patterns, the totals are not directly comparable until your plan is set in consultation. So we keep specific figures off a general guide like this one, rather than quote numbers that may not match your situation. For a fuller breakdown, see our page on skin booster cost in Dubai.
The best version of this decision is rarely about picking a winner. A short consultation with a DHA licensed practitioner maps the right choice, or the right combination, to your goal, so you are not left guessing from a chart. You can also explore the wider range of skin boosters in Dubai or book a consultation whenever you feel ready.
